Nouvelles catalyses pour accéder à la complexité moléculaire

Fensterbank, Louis (Université de Sorbonne)

Abstract: Organic radical chemistry involves highly reactive intermediates which evolution can be funnelled towards elaborated scaffolds. Thus, by carrying on several radical steps in a single reaction, one can reach molecular complexity from readily available precursors. Nevertheless, the efficient and sustainable generation of radical species has remained a challenge. Recently, new mild methodologies relying on catalytic transformations have been developed and opened new synthetic perspectives. For instance, from hypercoordinated silicon species as precursors of C-centered radicals, some new photoredox-nickel cross coupling dual catalysis reactions have been devised. In the same vein, electrophilic catalysis based on noble metals such as platinum and gold has proved to be a very performing strategy for the assembly of complex polycyclic derivatives, including natural products. It implies the π-activation of alkynes and allenes and can be coupled to a reductive photoredox catalysis.

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Published in: L'Actualité Chimique: N° 435 (Décembre 2018), p. 13-19

Note de localisation: CNUDST (TUN01)
Code de rangement: SP 1-3

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 Record created 2019-06-17, last modified 2019-07-08

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